| | S550 | S600 | S550 4MATIC | S63 AMG 4MATIC | S65 AMG |
| Body | |
| Sunroof/Moonroof | Std | | Std | |
| Exterior | |
| Side Mirrors - Power | Std | | Std | |
| Lighting | |
| Headlamp Type | LED | | LED | |
| Brakes | |
| ABS | Std | | Std | |
| Stability Control | Std | | Std | |
| Steering | |
| Power Assisted | Std |
| Wheels / Tires | |
| Wheel Type | Alloy | | Alloy | |
| Tire Size F (,R) | 255/45R18 | | 255/45R18 | 255/45R19, 285/40R19 | |
| Seating | |
| Seat Material | Leather | | Leather | |
| Power Adjustable Seats - 1st Row Driver Side | Std | | Std | |
| Power Adjustable Seats - 1st Row Passenger Side | Std | | Std | |
| Heated Seats - 1st Row | Std | | Std | |
| HVAC | |
| Air Conditioning | Std | | Std | |
| Automatic Climate Control | Std | | Std | |
| Climate Control Zones | 2 | | 2 | |
| Driving Aids | |
| Cruise Control | Std | | Std | |
| Infotainment | |
| Navigation System | Std | | Std | |
| Convenience | |
| Power Windows | Std | | Std | |
| Power Door Locks | Std | | Std | |
| Remote Lock/Unlock | Std | | Std | |
